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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: VARS All Species: 22.73
Human Site: S1085 Identified Species: 31.25
UniProt: P26640 Number Species: 16
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P26640 NP_006286.1 1264 140476 S1085 R M P Q A P P S L C V T P Y P
Chimpanzee Pan troglodytes XP_001160008 1264 140384 S1085 R M P Q A P P S L C V T P Y P
Rhesus Macaque Macaca mulatta Q5TM74 1064 118624 L932 K A R P R V L L Q S S E P G D
Dog Lupus familis XP_538837 1256 139671 S1085 R T L Q A P P S L C V T P Y P
Cat Felis silvestris
Mouse Mus musculus Q9Z1Q9 1263 140197 S1084 R T P K A P A S L C V T P Y P
Rat Rattus norvegicus Q04462 1264 140350 S1085 R T P N A P A S L C V T P Y P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001520676 985 109386 G853 L D V S R I L G Y R H F C N K
Chicken Gallus gallus
Frog Xenopus laevis NP_001088439 1243 140617 S1064 R P S S R T P S I S V T S Y P
Zebra Danio Brachydanio rerio XP_682807 1111 123867 T964 F V M S V V R T I R S L R A D
Tiger Blowfish Takifugu rubipres P49696 1217 138200 S1038 R P Q S D P P S I C V T P Y P
Fruit Fly Dros. melanogaster NP_524838 1049 118236 N917 R S D Y N L P N K V K T E V Y
Honey Bee Apis mellifera XP_395202 1043 121057 L911 S T R A T Y N L P N K I K T E
Nematode Worm Caenorhab. elegans Q9U1Q4 1050 118902 M918 L K K T K I T M Q I L S E T P
Sea Urchin Strong. purpuratus XP_001200958 1119 126755 M980 A V R S L E G M L G L K R G Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P93736 1108 125908 L974 E R L P A F A L C E N N V T S
Baker's Yeast Sacchar. cerevisiae P07806 1104 125751 I966 S L L S E Y N I L K N G K V F
Red Bread Mold Neurospora crassa P28350 1093 123334 F961 I K S D G R A F I K A T T A D
Conservation
Percent
Protein Identity: 100 99.5 43.4 92.8 N.A. 93.4 93.4 N.A. 63 N.A. 65.3 45 63.8 50.9 49.1 44.9 44.4
Protein Similarity: 100 99.8 56 95.6 N.A. 96.4 96.3 N.A. 69.8 N.A. 78 58.8 76.8 63.1 63.4 59.5 59.6
P-Site Identity: 100 100 6.6 86.6 N.A. 80 80 N.A. 0 N.A. 46.6 0 66.6 20 0 6.6 6.6
P-Site Similarity: 100 100 13.3 86.6 N.A. 86.6 80 N.A. 0 N.A. 53.3 20 73.3 26.6 0 20 20
Percent
Protein Identity: N.A. N.A. N.A. 41.6 42.6 40.3
Protein Similarity: N.A. N.A. N.A. 58.3 60.1 56
P-Site Identity: N.A. N.A. N.A. 6.6 6.6 6.6
P-Site Similarity: N.A. N.A. N.A. 6.6 13.3 13.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 6 6 0 6 36 0 24 0 0 0 6 0 0 12 0 % A
% Cys: 0 0 0 0 0 0 0 0 6 36 0 0 6 0 0 % C
% Asp: 0 6 6 6 6 0 0 0 0 0 0 0 0 0 18 % D
% Glu: 6 0 0 0 6 6 0 0 0 6 0 6 12 0 6 % E
% Phe: 6 0 0 0 0 6 0 6 0 0 0 6 0 0 6 % F
% Gly: 0 0 0 0 6 0 6 6 0 6 0 6 0 12 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 6 0 0 0 0 % H
% Ile: 6 0 0 0 0 12 0 6 24 6 0 6 0 0 0 % I
% Lys: 6 12 6 6 6 0 0 0 6 12 12 6 12 0 6 % K
% Leu: 12 6 18 0 6 6 12 18 42 0 12 6 0 0 0 % L
% Met: 0 12 6 0 0 0 0 12 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 6 6 0 12 6 0 6 12 6 0 6 0 % N
% Pro: 0 12 24 12 0 36 36 0 6 0 0 0 42 0 48 % P
% Gln: 0 0 6 18 0 0 0 0 12 0 0 0 0 0 6 % Q
% Arg: 48 6 18 0 18 6 6 0 0 12 0 0 12 0 0 % R
% Ser: 12 6 12 36 0 0 0 42 0 12 12 6 6 0 6 % S
% Thr: 0 24 0 6 6 6 6 6 0 0 0 53 6 18 0 % T
% Val: 0 12 6 0 6 12 0 0 0 6 42 0 6 12 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 6 0 12 0 0 6 0 0 0 0 42 6 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _